CASP3 and neoplasm: Conversely, apoptosis, as measured by cleaved caspase 3 positivity, was significantly higher in the core compared to the periphery (10.9 ± 3.5% in core vs. 2.1 ± 0.7% in periphery; P < 0.05; n = 9 tumours; paired t test; Fig. 5F).