While the list of cancers associated with poor prognosis involving HIF-1 (hepatocellular carcinoma [10], breast [11, 12], cervical [13], colorectal [14], gastric [15], oropharyngeal [16], ovarian [17] and pancreatic [18] cancer) or HIF-1/HIF-2 (head and neck squamous carcinoma [19], colorectal [20, 21], and lung [22] cancer) is extensive the array of cancers with poor prognostic implications primarily linked to HIF-2 alone is comparatively shorter. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.