Similarly, single cell meta data analysis (https://singlecell.broadinstitute.org/) by Manoranjan et al. [32] using primary patient-derived MB brain tumor-initiating cell (BTIC) lines showed low expression of Ca9, Lox, SLC16A3, ADM and Angpt1 in Group 3 MB in a context of high MYC expression compared to the other MB groups whereas SLC2A1, ldha, Mpzl1 and Oct4/Pou5f1, Icam4, the HIF1/2 and HIF-2 target genes, respectively, were expressed in Group 3 MB (Suppl. Here, HIF1A is linked to brain neoplasm.