In colorectal cancer, MORC2 binds to RBM39 to promote alternative splicing of pre-CDK5RAP2, converting CDK5RAP2 L into a variant CDK5RAP2 S. CDK5RAP2 S promotes invasion and metastasis of colon cancer cells in vitro and in vivo. Here, CDK5RAP2 is linked to colonic neoplasm.