Several studies have shown that HSPA8 inhibits ferroptosis by promoting SLC7A11/GSH/GPX4 signalling and inhibiting NCOA4-mediated ferritinophagy [33,34], We verified the effects of HSPA8 in liver cancer and found that LACTB promotes ferroptosis by regulating HSPA8-mediated ferroptosis-related signalling. The gene discussed is GPX4; the disease is liver cancer.