For example, in the genetic ablation model using CD11b–diphtheria toxin receptor (DTR) mice or treatment with liposomal clodronate, macrophage depletion resulted in improved renal function and mitigated pathological damage in response to acute ischemic kidney injury (60, 61) and unilateral ureteral obstruction (62). Here, ITGAM is linked to Ureteral obstruction.