EGFR and neoplasm: Canerpaturev (C-REV) is a spontaneous mutant of oHSV, originally isolated from the herpes simplex virus-1 (HSV-1) strain HF as clone 10 (formerly known as HF10), and is a cancer immunotherapeutic drug that combines direct killing of tumour cells with immunomodulation.EGFR plays an important role in the development and function of normal tissues.