INS and metabolic syndrome: However, only the genotype GG of rs743572 was independently associated with MetS (OR = 7.228, 95% CI: 3.925–11.331, P < 0.001) after adjusting for age, TT, E2, T/E, INS, FPG, SHBG, DHT, IPSS, Qmax, PSA, TPV, and HOMA-IR.