However, only the genotype GG of rs743572 was independently associated with MetS-BPH (OR = 3.417, 95% CI: 1.783–5.266, P < 0.001) after adjusting for age, TT, E2, T/E, INS, FPG, SHBG, DHT, IPSS, Qmax, PSA, TPV, and HOMA-IR. Here, KLK3 is linked to metabolic syndrome.