However, only the genotypes GG (OR = 5.868, 95% CI: 3.363–7.974, P < 0.001) of rs743572 were independently associated with BPH after adjusting for age, TT, E2, T/E, INS, FPG, SHBG, DHT, IPSS, Qmax, PSA, TPV, and HOMA-IR. This evidence concerns the gene INS and benign prostatic hyperplasia.