However, only the genotypes GG (OR = 5.868, 95% CI: 3.363–7.974, P < 0.001) of rs743572 were independently associated with BPH after adjusting for age, TT, E2, T/E, INS, FPG, SHBG, DHT, IPSS, Qmax, PSA, TPV, and HOMA-IR. The gene discussed is SHBG; the disease is benign prostatic hyperplasia.