The current study went further to detect the middle-aged male crowd SNPs (rs743572, rs3781287, and rs4919686) of CYP17A1, and the research shows that genotypes GA and AA of rs743572, genotypes GG, GT, and TT of rs3781287, and genotypes CC, CA, and AA of rs4919686 were not associated with BPH, MetS, and MetS-BPH. The gene discussed is CYP17A1; the disease is metabolic syndrome.