Only the genotype GG of rs743572 was independently associated with BPH, MetS, and MetS-BPH after adjusting for age, TT, E2, T/E, INS, FPG, SHBG, DHT, IPSS, Qmax, PSA, TPV, and HOMA-IR. Here, KLK3 is linked to benign prostatic hyperplasia.