Through transcriptional stimulation of positive regulators of P-body formation (AJUBA, WTIP, and SAMD4A) and suppression of negative regulators of P-body formation (PNRC1), YAP enhances P-body formation and increases the number of P-bodies in cancer cells, which suggests that YAP is a positive regulator of P-body formation (Figure 7D). This evidence concerns the gene SAMD4A and cancer.