Intriguingly, the public TEAD4 ChIP-seq datasets for the other three cancer cell lines (A549, MCF7, and MDA-MB-231), not just HCT116 cells, also showed strong TEAD4 binding peaks in the genomic loci of these five P-body-related genes (Figure 1—figure supplement 1B; Mei et al., 2017). Here, TEAD4 is linked to cancer.