Furthermore, our study showed that disruption or attenuation of P-body formation by knockdown of YAP-regulated P-body-related genes or the P-body core genes (DDX6, DCP1A, LSM14A) suppressed YAP-induced oncogenic phenotypes in CRC cells, such as cell proliferation and cell migration, further indicating the protumorigenic function of P-bodies in CRC or at least in CRC with active YAP. Here, DDX6 is linked to colorectal carcinoma.