Next, we confirmed the significantly downregulated mRNA expression of AJUBA, WTIP, SAMD4A, and NOCT and moderately increased expression of PNRC1 in YAP/TAZ knockdown HCT116 cells by qPCR analysis; this pattern was also observed in A549 lung cancer cells and MDA-MB-231 breast cancer cells (Figure 1C). The gene discussed is SAMD4A; the disease is lung cancer.