In this study, it was predicted that T. gondii may cause epilepsy in patients with idiopathic epilepsy by acting through the NF‐κB signalling pathway and it was aimed to determine the gene expression levels of HMGB1, RAGE, TLR4, TLR1, TLR2, TLR3, IRAK1, IRAK2, IKBKB, IKBKG, BCL3, IL1β, IL10, 1 L8 and TNFα associated with this signalling pathway. The gene discussed is IKBKB; the disease is epilepsy.