found that increased translocation of HMGB1 from the nucleus to the cytoplasm has significantly increased TLR4 protein levels, cytoplasmic HMGB1, and inflammatory factors such as IL‐1β and tumour necrosis factor‐α (TNF‐α) in FCD pathological tissues compared to controls.47 Here, HMGB1 is linked to fleck corneal dystrophy.