In this study, it was predicted that T. gondii may cause epilepsy in patients with idiopathic epilepsy by acting through the NF‐κB signalling pathway and it was aimed to determine the gene expression levels of HMGB1, RAGE, TLR4, TLR1, TLR2, TLR3, IRAK1, IRAK2, IKBKB, IKBKG, BCL3, IL1β, IL10, 1 L8 and TNFα associated with this signalling pathway. This evidence concerns the gene TLR3 and epilepsy.