MAPK8 and tuberculosis: To assess the effects of currently commonly used anti-tuberculosis drugs on host innate immune signaling pathways, we used a dual fluorescence reporting system to detect drug effects on NF-κB pathway, JNK pathway, and ERK pathway in HEK293T, including isoniazid (INH), rifampicin (RFP), pyrazinamide (PZA), ethambutol (EMB), clofazimine, TBI-166, and bedaquiline (BDQ).