We additionally identified a variant near Heparin Binding EGF like growth factor (HBEGF), a growth factor implicated in the pathobiology of cerebral autosomal dominant arteriopathy with sub‐cortical infarcts and leukoencephalopathy (CADASIL),52 the major Mendelian prototype of VaD. The gene discussed is HBEGF; the disease is Leukoencephalopathy.