ACD exhibits genetic pleiotropy with vascular risk factors (hypertension, WMH burden), hematological traits (neutrophil, lymphocyte count), and blood‐based biomarkers indicative of inflammation (C‐reactive protein levels), hemostasis (fibrinogen, factor‐VII levels), and neurodegeneration (soluble TREM2 levels) (Table S6). Here, TREM2 is linked to hypertensive disorder.