In our ACD analysis of European ancestry, we identified 10 GW significant loci, including APOE, BIN1, MS4A6A, PICALM, CR1, CD2AP, ABCA7, PILRB, SLC24A4, and ACE, all of which have been linked with AD risk in prior studies.45 The gene discussed is PICALM; the disease is Alzheimer disease.