PWRN2 and tauopathy: We identified novel signals reaching GW significance at 20q11.21 (CHD6, an oxidative DNA damage response factor previously associated with neurological phenotype),41 2q14.1 (DAW1, involved in cerebrospinal fluid circulation and cilia motility during development),42 and 15q15.1 (PWRN2, previously associated with tauopathy and Prader–Willi syndrome)43 for ACD and 17q21.1 (MARCHF10) for VaD.