This gene may also impact dementia risk through non‐amyloidogenic pathways as it additionally regulates neuron development and neuronal excitability, including brain‐derived neurotrophic factor (BDNF)‐dependent long‐term potentiation in the hippocampus and has been implicated in brain development, essential tremor, and schizophrenia.50 The gene discussed is BDNF; the disease is essential tremor.