BTG3 and systemic sclerosis: The most relevant SSc-associated autoantibodies are antinuclear autoantibodies (ANA), particularly antitopoisomerase-I antibodies (ATA; anti-Scl70), anticentromere antibodies (ACA), and anti-RNA polymerase III antibodies (ARA), which are routinely assessed for diagnosis, clinical subset classification, and prognosis [1–3].