By means of a proteome-wide planar antigen array on a small cohort of SSc patients, antiphosphatidylinositol-5-phosphate 4-kinase type 2 beta (PIP4K2B) and anti-AKT serine/threonine kinase 3 (AKT3) antibodies were found to be the most promising candidates as potential skin and lung fibrosis-associated autoantibodies in SSc [56]. This evidence concerns the gene PIP4K2B and systemic sclerosis.