CD8A and listeriosis: Upon uptake by memory CD8+ T cells, acetate increased the acetyl-coenzyme A (acetyl-CoA) pool and promoted the acetylation of GAPDH and glycolysis rate, which further facilitated the rapid memory CD8+ T response and IFN-γ production to control Listeria monocytogenes infection.108 The transition of activated CD8+ T cells into memory cells has also been reported to be microbiota-dependent.