Resistin also enhances the expression of TNF-α and IL-1β via MEK and ERK signaling pathways by inhibiting some microRNAs8,22,23, Consequently, a growing body of evidence corroborates the hypothesis that resistin and its gene, RETN, may play a role in the development and progression of NAFLD, and the finding of the present study that the −420C>G polymorphism of RETN gene is associated with NAFLD is in line with the above evidence. This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.