Finally, significant associations between variants in insulin signaling pathway genes including insulin receptor (INSR), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) and the risk of NAFLD have been discovered2-7. The gene discussed is IRS2; the disease is metabolic dysfunction-associated steatotic liver disease.