In multiple sclerosis patients, iron is stored in oligodendrocytes and myelin in the normal appearing WM and GM, whereas it is also found in microglia/macrophages and astrocytes in active and chronic active lesions.37 In contrast to healthy controls, iron appears to decrease with age in the subcortical WM of people with multiple sclerosis,37 although it is relatively increased in the peri-plaque tissue.37 Similarly, iron transport (Hephaestin) and oxidation (Ceruloplasmin) are increased in surrounding multiple sclerosis lesions.37 This evidence concerns the gene HEPH and multiple sclerosis.