BIN1 has also been found to be a regulator of transverse tubule function and calcium signaling in cardiomyocytes, and is associated with abnormal cardiac contraction, increasing the likelihood of malignant arrhythmias before heart failure (58); plasma levels of cardiac bridging integrator 1 (cBIN1) also indicative of the effects of coronary microvascular dysfunction on cardiomyocytes (59). The gene discussed is BIN1; the disease is heart failure.