,251 In a clinical trial, cationic liposomes carrying anti-vascular endothelial growth factor (VEGF) and anti-kinesin spindle protein (KSP) siRNA, known as ALN-VSP, showed an increased uptake in tumor cells and significant downregulation of VEGF and KSP levels when administered to patients with multiple types of cancer (Table 2).51 The gene discussed is VEGFA; the disease is neoplasm.