Univariable logistic regression analysis showed that being male, PPM, MR (≥3°), TR (≥3°), and AF, and higher BSA, lower LVEF, larger LAV and LVEDV, lower eGFR, and higher NT-pro BNP levels were significantly associated with the lowest CPO group, using the continuous variable format (Table 4). The gene discussed is NPPB; the disease is atrial fibrillation.