Multivariable Cox regression analysis revealed that lower CPO, larger LAV, higher SPAP, and AF were independently associated with event risk (HR = 0.561, 0.992, 1.031, and 1.545, P = 0.020, 0.021, <0.001, and P = 0.031, respectively; Table 3). The gene discussed is CPO; the disease is atrial fibrillation.