SOX2 and cancer: Previous studies have determined a direct role for the SS18-SSX fusion protein in regulating expression of several cancer-related genes, such as EGR1 (Lubieniecka et al., 2008), FOS (Su et al., 2012), IGF2 (de Bruijn et al., 2006; Sun et al., 2006), FZD10 (Tamaki et al., 2015), SOX2 (Kadoch and Crabtree, 2013), UNCX (Banito et al., 2018; Brien et al., 2018) and CDH4 (Boulay et al., 2021).