As shown in Figure 3F, signalling circuits related to Toll-like receptor (TLR), p53, foxO, Nf-kB, erbB and TGFβ were upregulated in the DMD FAPs condition while circuits related to Ras signalling, Kat-STAT, TNF or Notch pathways were upregulated in the healthy control FAPs condition. The gene discussed is TNF; the disease is Duchenne muscular dystrophy.