• IGFBP7 isolated from conditioned media of human bladder carcinoma cells did not stimulate growth or migration, but enhanced adhesion of HUVECs when protein was coated on to cell culture plate• Promoted the retraction of HUVECs by inducing actin stress fibers and loosening their VE-cadherin-mediated intercellular junction• Increased permeability of HUVEC monolayer• Intradermal injection increased vessel permeability near the injection site in mice. This evidence concerns the gene IGFBP7 and urinary bladder carcinoma.