Congruently, increased VEGF levels were recorded in lung tumors of IGFBP7−/− mice (Akiel et al., 2017) and administration of exogenous IGFBP7 reduced VEGF expression in breast cancer cell lines 1833 xenografts implanted in mice (Benatar et al., 2012). This evidence concerns the gene IGFBP7 and breast cancer.