AKT1 and gastric cancer: Treatment of macrophages and gastric cancer cells with recombinant IGFBP7 further showed that IGFBP7 promoted tissue-associated macrophages (TAM)/M2 polarization via FGF-2/Fibroblast Growth Factor Receptor 1 (FGFR-1)/Phosphoinositide 3-kinases (PI3K)/Protein kinase B (Akt) axis (Li D. et al., 2023).