IGFBP7 and malignant colon neoplasm: Other reports indicated that endogenously expressed IGFBP7 had no significant effects on insulin signaling in the IGFBP7-expressing human bladder carcinoma cell line EJ-1 and the human colon cancer cell line DLD-1 transfected with the IGFBP7 gene (Sato et al., 2007).