IGFBP7 knockout significantly decreased lipid accumulation, inflammation, and liver fibrosis, whereas liver-specific IGFBP7 overexpression dramatically exacerbated liver fibrosis in the zebrafish NAFLD model, suggesting that IGFBP7 may act as an important regulator in NAFLD progression (Wang et al., 2023). This evidence concerns the gene IGFBP7 and Hepatic fibrosis.