IGFBP7 and metabolic dysfunction-associated steatotic liver disease: IGFBP7 knockout significantly decreased lipid accumulation, inflammation, and liver fibrosis, whereas liver-specific IGFBP7 overexpression dramatically exacerbated liver fibrosis in the zebrafish NAFLD model, suggesting that IGFBP7 may act as an important regulator in NAFLD progression (Wang et al., 2023).