IGFBP7 and neoplasm: Since it has been implicated by studies of physiological angiogenesis that IGFBP7 acts in synergy with other ECM components (Newman et al., 2011; Wan et al., 2021; Lam et al., 2022) and that IGFBP7’s bioactivity is dependent on the microenvironment, conflicting results observed in tumor angiogenesis and progression may be explained by differences in the composition of the TME in which IGFBP7 is embedded in.