Additionally, another study demonstrated that in chemoresistant ovarian cancer cells (SKOV3-CIS and A2780-CIS), inhibiting SCD1 expression by activating the AMPKα signaling pathway can induce ferroptosis, enhance the sensitivity of ovarian cancer cells to platinum-based drugs, and reverse chemoresistance (Tang et al., 2022). This evidence concerns the gene SCD and in situ carcinoma.