By co-delivering negatively charged small interfering RNA against baculoviral IAP repeat containing 5 (siBIRC5) and antisense oligodeoxynucleotide (AS-ODN), MNPs down-regulated the expression of BIRC5 in lung adenocarcinoma and improve the absorptivity of AS-ODN and small interference RNA (siRNA), which can inhibit gene. This evidence concerns the gene BIRC5 and lung adenocarcinoma.