TGFB1 and neoplasm: This environment is characterized by the presence of immune-related cells and regulators that suppress the immune response, including tumor-associated macrophages (TAMs) with the M2 phenotype, myeloid-derived suppressor cells (MDSCs), regulatory T cells (Treg cells), and cytokines such as interleukin-10 (IL-10) and transforming growth factor-β (TGF-β).