Further analysis of DMR-associated genes identified a variety of genes closely linked to mastitis in cattle, namely, PIK3R2, PLCB1, EGFR, JAK2, PLCG2, GNG7, GNG13, PTEN, GNAI1, MAPK1, PRKCB, PRKCD, and STAT3, among others, suggesting the potential involvement of these genes in regulating the occurrence and development of mastitis in Xinjiang brown cattle. Here, PIK3R2 is linked to mastitis.