DPY19L2 is the most common gene involved in the etiology of globozoospermia, and the more common pathogenic variant is the deletion of the entire gene, which has been reported to have a prevalence ranging from 22.2% to 83.3% (Abdelhedi et al., 2019; Shang et al., 2019). The gene discussed is DPY19L2; the disease is Globozoospermia.