DNAH5 and primary ciliary dyskinesia: This report summarises the genetic and functional analyses of ciliated respiratory epithelial cells from five PCD individuals with variable laterality defects who inherited novel pathogenic variants of DNAH5. Immunofluorescence (IF) and transmission electron microscopy (TEM) analyses show the complete absence of the dynein arm protein component DNAH5 as well as the absence of the axonemal ODAs in all five PCD individuals.