PPARA and Acute hepatitis: Isorhamnetin application can improve the pathological injury of mouse liver tissue, lower serum liver enzyme and pro-inflammatory factor levels, and down-regulate the levels of Bax, cleaved Caspase-3, cleaved Caspase-9, Beclin-1, and p-P38/P38 in the mouse model of acute hepatitis caused by canavin A. Isorhamnetin’s hepatoprotective impact was achieved by inhibiting autophagy and apoptosis through the P38/PPAR-α signaling pathway, as evidenced by the up-regulation of PPAR-α level (63).