Inhibit the proliferation of tumor cells and induce apoptosis; the levels of p-Akt, p-mTOR, p-MEK1/2, p-ERK1/2, Bcl-2 and Bcl-xL are down-regulated, and the level of cleaved-Caspase 3 is up-regulated. This evidence concerns the gene MAP2K1 and neoplasm.