As myosin activators improve SV through prolonging SET,5 this parameter received increasing attention as an easily accessible imaging biomarker in HF.11 SET is reduced in patients with HFrEF and correlates with decreased LVEF, SV, and global longitudinal strain.11 Shortened SET was an independent predictor of incident HF in a community-based cohort of individuals without prior HF and predicted death or hospitalization for HF in patients with HFrEF, but not HFpEF.11 Here, MYH14 is linked to hydrops fetalis.