CAMK2G and hydrops fetalis: At the same time, prolonged SETc may serve as an indicator of an increased cardiac risk, since CaMKII activation is a known prohypertrophic factor that may contribute to the development of HF.23 We consider the Anrep effect19 a more likely explanation of age-dependent SETc prolongation than an increase in sympathetic tone, since adrenergic stimulation shortens SET.24