In a large genetic study conducted in >1000 SCAD patients and ∼7200 controls, associations were reported between rs9349379, a common non-coding variant in the PHACTR1/EDN1 locus, and the risk of SCAD.22 Moreover, rare familial cases composed of two or more affected relatives have been reported, implicating a hereditary predisposition.23 Despite the recent advances in SCAD susceptibility gene discoveries, it remains to be determined if they translate into clinically useful genetic testing to predict recurrence or risk in unaffected family members. Here, PHACTR1 is linked to spontaneous coronary artery dissection.