AGT and cardiac hypertrophy: In cardiovascular research, CypA knockout (Ppia −/−) models have demonstrated a crucial role in modulating angiotensin II-induced cardiac hypertrophy: Ppia −/− mouse show a marked reduction in cardiac hypertrophy, pointing towards CypA’s involvement in the direct potentiation of ROS production, which in turn stimulates cardiac fibroblast proliferation and cardiac myocyte hypertrophy.