Within the context of neurodegenerative disorders, CypB’s importance is further emphasized by the work of Oh et al. (Oh et al., 2011), who demonstrated the overexpression of CypB mitigates neuronal apoptosis in Alzheimer’s disease models, particularly in scenarios characterized by the aggregation of amyloid proteins. The gene discussed is PPIB; the disease is early-onset autosomal dominant Alzheimer disease.