In cardiovascular research, CypA knockout (Ppia −/−) models have demonstrated a crucial role in modulating angiotensin II-induced cardiac hypertrophy: Ppia −/− mouse show a marked reduction in cardiac hypertrophy, pointing towards CypA’s involvement in the direct potentiation of ROS production, which in turn stimulates cardiac fibroblast proliferation and cardiac myocyte hypertrophy. Here, PPIA is linked to cardiac hypertrophy.