This impact could occurs through i) an increase of intracellular Ca2+ concentration causing the activation of PKA and inducing the expression of RhoA and Rac1, ii) EGF/EGFR activation leading to the activation of ERK1/2 pathway and Src kinase activation, iii) upregulating the expression of MACC1, which enhances the Warburg effect, c-MET synthesis, and NHE-1 formation, consequently activating ERK1/2, Src kinase, and increasing the ECM protease secretion and iv) an increase in intracellular [Na+] can depolarize Vm, disrupt pH balance and alter metabolic activity in cancer cells. This evidence concerns the gene MAPK3 and cancer.