MACC1 and gastric cancer: The effect of NaV1.7 on gastric cancer (GC) prognosis was investigated in 2016 by Xia et al. The study found significant correlations between the expression levels of NaV1.7, NHE-1 (Na+/H+ exchanger type 1), and MACC1(metastasis-associated with colon cancer-1) in 319 GC patient samples (Xia et al., 2016).