In AD, the combination of glmBoost and LDA with higher average AUC (0.764) and proper genes (N = 17) was selected as the final model, which contained BLVRB, C10orf54, CDC37, CHCHD6, FKBPL, FN1, GLUL, HOXC4, PFN1, PPIL1, PRDX4, PSMB1, PSMG1, SLC16A14, SLC17A7, SMYD3, and SYK. This evidence concerns the gene PSMB1 and Alzheimer disease.