CRB3 and Parkinson disease: In addition, we also identified 344 DEPs between PD and healthy controls (|Fold change| ≥ 1.2 and p-value < 0.05), including 90 upregulated (VEGF, RASL11B, CRB3, DBF4B, and PCBD2) and 254 downregulated proteins (ERO1LB, C1orf162, WDR22, MTMR2, and RABEP2) (Figure 2B).