The present study examined this, utilizing a combined approach by predicting mortality using genetic GWAS hits combined with a metabolite profile to identify novel candidate genes for HF (COX1, ARHGEF28, and TEN1) and underscoring key gene ontology groups (33) that likely have impact in HF development and progression (metabolic and apoptotic pathways, among others). Here, ARHGEF28 is linked to hydrops fetalis.