CCL2 and neoplasm: We categorized the macrophages into three primary classes: (1) the classically activated M1 subtype, hallmarked by elevated CD86 and IL1B expression; (2) the alternatively activated M2 group, distinguished by MRC1 and CD163 expression; and (3) the tumor-associated macrophages (TAMs), identified by CCL2 and PDGFB expression [9].