Analysing wait-list changes in total tumor volume, HCC count, and alpha-fetoprotein levels, and assessing survival from listing and transplantation; TIPS correlated with a decreased nodule count (−0.24 vs. 0.04, p = 0.028) over a median wait period of 284 days (IQR 195–493) and better overall survival from listing (95.6% vs. 91.5% at 1 year, p < 0.0001). This evidence concerns the gene AFP and hepatocellular carcinoma.