LPA and atherosclerosis: Greater awareness of the role of Lp(a) in cardiovascular diseases means that new strategies for treating conditions that cause high Lp(a) are being sought [17]. Because elevated Lp(a) levels are largely genetic and have been linked to the process of atherosclerosis formation, coronary artery disease, ischemic stroke, and higher rates of heart failure, therapies designed to lower Lp(a) levels could have important implications in preventative treatment plans.