Additionally, geographical analysis of the two extreme responders revealed distinct clustering of exhausted CD8+ T-cells with PD-L1+ macrophages in the first extreme responder, and exhausted CD8+ T-cells with cancer cells harbouring genomic PD-L1 and PD-L2 amplification in the second extreme responder (Färkkilä et al., 2020). This evidence concerns the gene CD274 and cancer.