We observed a proportional decrease in B naïve cells (mean 28,4% vs 5,8%) and NK CD16– cells (mean 21,4% vs 8,1%), along with a significant increase in CD4+- (mean 19,2% vs 42,6%) and CD8+ T cells (mean 13,9% vs 25,5%), comparing HIS control vs HIS PM-CRC, respectively (Figures 2E, F). Here, CD4 is linked to colorectal carcinoma.