Interestingly, the observed Treg responses in MSS PM-CRC (MDST8 and HUTU80) of HIS mice was also observed in the human PerIS in the setting of peritoneal metastasized MSS CRC (mean 7,0% vs 12,11% and 7,7% vs 26,5%, respectively (Figure 3C) while no changes were observed in CD8+ TEMs in PF of HIS mice nor human PF (Figure 3C). This evidence concerns the gene CD8A and colorectal carcinoma.