Ranked by mediation proportion, CD127 on granulocyte mediated 10.6% of the total effect of MS on TMDs, followed by CD25++ CD8+ T cell % CD8+ T cell mediating the causal effect of RA on TMDs (6.2%), and CD3 on activated CD4 regulatory T cell (5.4%) (Figure 4). The gene discussed is CD8A; the disease is rheumatoid arthritis.