In the case of LC and infectious ME/CFS, adjuvants that could induce hyperactivation and depletion of the immune system by chronic exposure would be viral antigens, interacting with genetically predisposed HLA-II alleles (HLA-DRB1), similar to ASIA syndrome (61). The gene discussed is HLA-DRB1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.