It is believed that adjuvants such as aluminum salts, emulsions, oils, spike (S) protein, Toll-like receptor agonists, mRNA vaccine lipids, and polyethylene glycol could promote immune hyperactivation with autoimmunity in genetically susceptible individuals (HLA-DRB1) (20, 36, 62, 72–75). Here, HLA-DRB1 is linked to Autoimmunity.