Autoimmune hypophysitis or elevated TNF-α levels could suppress ACTH secretion in the pituitary and, together with chronic exposure to IL-10, TGF-β1 and TNF-α and hyperinsulinemia could also suppress ACTH-stimulated cortisol secretion in the adrenal gland (43, 44, 163–169). The gene discussed is POMC; the disease is Hyperinsulinemia.