MAPT and Alzheimer disease: In animal models, estradiol (E2) influences the severity of AD biomarkers by preventing amyloid accumulation (Xu et al., 1998; Nilsen et al., 2006; Amtul et al., 2010; Kim et al., 2022) and tau hyperphosphorylation (Alvarez-De-La-Rosa et al., 2005).