Also, the encapsulations of melatonin, siAPE1, and 125I radioactive particles were efficient therapies for the treatment of PCa, as the Mel@PSMA-R12-125I/siAPE1 nanocomposites inhibited cell proliferation in LNCaP and DU145 cells in vitro and suppressed PCa tumor growth in vivo. Here, FOLH1 is linked to posterior cortical atrophy.