Importantly, seven factors, namely rheumatoid arthritis (RA) (57), diabetes (51), depression (58), homocysteine (55), folic acid (55), clusterin in cerebrospinal fluid (59), and cognitive activity (60), exhibited remarkably significant effects at p < 10−6 (Table 1, Supplementary Table 2). The gene discussed is CLU; the disease is rheumatoid arthritis.