TNF and Huntington disease: A functional enrichment analysis focusing on MSigDB Hallmark gene sets showed that genes specifically up-regulated in SCD cells (Figure 4C) were involved in biological states or processes such as TNF-α signaling via NFKB, inflammatory response, interferon alpha, and gamma response (Table S7); conversely, genes specifically up-regulated in HD cells showed no enrichment in no specific gene signature (Table S7).