On the one hand, while the alteration of RCAN1‐CaN‐TFEB axis discovered from longitudinal comparison of healthy‐MSNs reflected a more general age‐related autophagy decline that can contribute to HD disease onset, the changes in the miR29B1‐3p‐STAT3 axis observed in symptomatic old‐HD‐MSNs might be a consequence rather than a cause of HD pathology. Here, NUP214 is linked to Huntington disease.