To this end, we identified TRPM2 as an important gene whose expression was substantially inhibited at both mRNA and protein levels in sensitive EGFRm NSCLC cells exposed to osimertinib and other EGFR‐TKIs and was elevated in several EGFRm cell lines with acquired resistance to osimertinib. This evidence concerns the gene EGFR and non-small cell lung carcinoma.