TRPM2 and cancer: In cancer cells including lung cancer cells, TRPM2 has been linked to supporting cell survival by negative regulation of ROS production and maintenance of DNA repair function[2, 3, 13, 19] and accordingly, inhibition of TRPM2 enhanced ROS production,[20, 21] DNA damage[13, 22, 23] and apoptosis.[13, 22, 23] Therefore, we further determined the effects of osimertinib on the induction of ROS production and DNA damage in EGFRm NSCLC cells.