Aberrant TRPM2 function has been implicated in inflammatory diseases,[3] several neurological disorders including ischemia/stroke, Alzheimer's disease, neuropathic pain, Parkinson's disease and bipolar disorder,[4] and cancer.[2, 5] Thus, TRPM2 has been considered a promising therapeutic target for the treatment of these diseases.[6]. The gene discussed is TRPM2; the disease is early-onset autosomal dominant Alzheimer disease.