It is currently recognized that the presence of primarily resistant clones and drug tolerant persister cells (DTCs) in sensitive EGFRm NSCLC cell populations represents a primary mechanism accounting for the emergence of acquired resistance to EGFR‐TKIs.[28, 29] We found that three cell lines with primary resistance to osimertinib, which were originally derived from PC‐9 cells,[30] possessed elevated levels of TRPM2 (Figure 7A). Here, TRPM2 is linked to non-small cell lung carcinoma.