When patients were stratified by Gleason sum (GS), the top 10 TF network activity, which is the Z-score of union set of the 10 TFs target genes, showed a significant difference between Black and White men in all tumor grades, though this only reached significance in GS < 7 and GS = 7 (Fig. 6B; GS < 7, P = 0.0101; GS = 7, P < 0.0001). The gene discussed is TF; the disease is neoplasm.