In BAA HNSCC, the 5 most commonly mutated genes were TP53, TTN, MUC16, KMT2D, and CSMD3 (Fig. 2B and D), while in White HNSCC, TP53, TTN, FAT1, CDKN2A, and NOTCH1 were the 5 most commonly mutated genes (Fig. 2C and supplementary Fig. S2). The gene discussed is NOTCH1; the disease is head and neck squamous cell carcinoma.