We then investigated the proportions of the four cell subtypes in samples and found that the proportion of Mono_CD14 cells in sepsis patients was significantly lower than that in the healthy controls, while the proportions of Mono_CD16, Macro_ISG15 and Macro_C1QC cells were significantly higher than those in the healthy controls (Figure 3C,D). This evidence concerns the gene FCGR3A and Sepsis.