EGR1 and neoplasm: To confirm the role of WTAP, EGR1, and PTEN in tumor growth in vivo, we constructed xenograft tumor models in nude mice by subcutaneous injection of overexpression of WTAP, EGR1, and PTEN in ECCs and ECSCs, respectively, or combined overexpression of WTAP + EGR1 or EGR1 + PTEN.